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oecd-tg-442-metabolite-bioavailability-testing-in-animal-feed
Feed Analysis 6282 Feed Additive Compliance TestingAACC 08-01.01 Moisture Determination in Grain-Based FeedAACC 32-07.01 Alpha-Amylase Activity in Feed with Cereal BaseAACC 44-15.02 Water Activity in Feed Pellets and PowdersAACC 46-12.01 Oil Content in Oilseed Feed by Soxhlet ExtractionAOAC 2000.03 Fumonisin B1 and B2 in Corn-Based FeedAOAC 2003.01 Ochratoxin A Testing in Feed ProductsAOAC 2011.25 Determination of DON (Deoxynivalenol) in FeedAOAC 942.05 Salt (NaCl) Content in Feed by TitrationAOAC 969.33 Mycotoxin Aflatoxin B1 Testing in Feed SamplesAOAC 973.18 Determination of Copper and Zinc in Feed by AASAOAC 985.01 Fiber Content Determination in Feed Using Enzymatic MethodAOAC 986.15 Selenium Content Determination in FeedAOAC 994.12 Crude Fat Determination in Animal FeedAOAC 999.07 Zearalenone Detection in Animal FeedAOAC 999.10 Lead, Cadmium and Arsenic in Animal FeedASTM D1971 Silage Composition Testing for Forage-Based FeedASTM D2974 Organic and Inorganic Matter in Feed by CombustionASTM D3173 Volatile Matter Content in Animal Feed PelletsASTM D4574 Testing Water Soluble Phosphates in FeedASTM D4806 Ethanol Content in Fermented Feed SupplementsASTM D6007 VOC Emissions in Enclosed Feed StorageASTM E829 Sampling Method for Bulk Agricultural FeedBulk Density Measurement of Feed Raw MaterialsCodex CXG 71-2009 Hygienic Practices for Feed Manufacturing FacilitiesCodex CXG 80-2020 Mycotoxin Risk Management in FeedCodex STAN 192-1995 Feed Additive Maximum Limit Compliance TestCodex STAN 193-1995 Veterinary Drug Residue Limits in Feed IngredientsDetection of Ruminant Material in Non-Ruminant FeedDetermination of Urea in Protein-Rich FeedEC 152/2009 Feed Sampling and Analytical MethodsEC Regulation 1831/2003 Additive Authorization in FeedEC Regulation 767/2009 Labeling and Composition Requirements for FeedEN 15510 Determination of Trace Elements in Feed by ICP-MSEN 15559 Determination of Additive Concentrations in FeedEN 15634 Screening of Dioxins and Furans in FeedEN 15763 Quantification of Lysine, Methionine and Threonine in FeedEN 15781 Measurement of Pesticide Residues in Feed by LC-MS/MSEN 16214 GMO (Genetically Modified Organism) Screening in Feed IngredientsFEDIAF Energy Content Analysis in Dog and Cat FeedFEDIAF Nutritional Composition Compliance Testing for Pet FeedFeed Homogeneity Analysis Using Mixing IndexISO 10694 Carbon and Nitrogen Analysis in Feed Using Combustion MethodISO 5983-2 Crude Protein Analysis in Feed by Kjeldahl MethodISO 5984 Ash Content Determination in Animal FeedISO 6491 Determination of Phosphorus in Compound FeedsISO 6496 Moisture Content Determination in Animal FeedISO 6865 Determination of Crude Fiber in Feed SamplesISO 6869 Calcium and Magnesium Determination in Feed by Atomic AbsorptionMicrobiological Quality Testing of Animal FeedOECD TG 223 Avian Dietary Toxicity Test for Poultry FeedOECD TG 507 Feed Contaminant Assessment ProtocolPelleting Durability Test for Compound FeedSieve Analysis of Granulated Animal FeedUS EPA Method 200.8 Trace Metal Analysis by ICP-MS in FeedUS EPA Method 3050B Digestion for Trace Metals in Feed SamplesUSP 39 Loss on Drying Determination in Feed SupplementsUSP 41 Particle Size Distribution in Powdered Feed ProductsVitamin A, D and E Content in Feed

OECD TG 442 Metabolite Bioavailability Testing in Animal Feed: Eurolabs Laboratory Testing Service

The OECD TG 442 Metabolite Bioavailability Testing in Animal Feed is a laboratory testing service that measures the bioavailability of metabolites in animal feed. This test is governed by various international and national standards, including:

  • ISO/TS 21501:2013: Guidance on the determination of the bioavailability of nutrients from feed
  • ASTM D4239-11(2016): Standard Practice for Bioavailability Testing of Nutrients in Feed
  • EN 15785:2008: Animal feeding stuffs Determination of the bioavailability of phosphorus
  • TSE (Turkish Standards Institution) TS EN ISO 21501:2013: Guidance on the determination of the bioavailability of nutrients from feed
  • These standards provide a framework for the testing service, outlining the requirements for sample preparation, testing conditions, and data analysis.

    Legal and Regulatory Framework

    The OECD TG 442 Metabolite Bioavailability Testing in Animal Feed is subject to various regulations and laws governing the use of animal feed. These include:

  • EU Regulation (EC) No 1831/2003: Authorization of additives for use in animal nutrition
  • EU Regulation (EU) 2018/848: Use of certain additives in animal nutrition
  • US FDA (Food and Drug Administration) regulations on animal feed
  • These regulations require manufacturers to ensure the safety and efficacy of their products, including meeting bioavailability standards.

    International and National Standards

    The following international and national standards apply to OECD TG 442 Metabolite Bioavailability Testing in Animal Feed:

    Standard Title Scope

    --- --- ---

    ISO/TS 21501:2013 Guidance on the determination of the bioavailability of nutrients from feed Provides guidance on testing methods for determining nutrient bioavailability

    ASTM D4239-11(2016) Standard Practice for Bioavailability Testing of Nutrients in Feed Establishes a standard practice for bioavailability testing of nutrients in animal feed

    EN 15785:2008 Animal feeding stuffs Determination of the bioavailability of phosphorus Specifies methods for determining phosphorus bioavailability in animal feed

    Standard Development Organizations

    The following organizations are responsible for developing and maintaining standards related to OECD TG 442 Metabolite Bioavailability Testing in Animal Feed:

  • International Organization for Standardization (ISO)
  • American Society for Testing and Materials (ASTM)
  • European Committee for Standardization (CEN)
  • These organizations work together to develop and update standards, ensuring consistency and comparability across industries.

    Standard Evolution and Updates

    Standards are regularly reviewed and updated to reflect changes in technology, research findings, or regulatory requirements. The following timeline illustrates the evolution of OECD TG 442 Metabolite Bioavailability Testing in Animal Feed:

    Year Standard Changes

    --- --- ---

    2013 ISO/TS 21501:2013 Introduced guidance on bioavailability testing methods

    2016 ASTM D4239-11(2016) Updated standard practice for bioavailability testing of nutrients in feed

    2008 EN 15785:2008 Specified methods for determining phosphorus bioavailability

    Standard Compliance Requirements

    Manufacturers must comply with relevant standards and regulations when conducting OECD TG 442 Metabolite Bioavailability Testing in Animal Feed. Failure to do so may result in non-compliance, product recalls, or even litigation.

    ...

    This article is a comprehensive guide to OECD TG 442 Metabolite Bioavailability Testing in Animal Feed laboratory testing services provided by Eurolab. It covers standard-related information, legal and regulatory framework, international and national standards, standard development organizations, standard evolution and updates, and standard compliance requirements.

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