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oecd-407-repeated-dose-dermal-toxicity-test
Azo & Formaldehyde Testing ASTM D1331 Formaldehyde Emission Test in TextilesASTM D5035 Identification of Formaldehyde in Textile SamplesASTM D5036 Determination of Formaldehyde by Chromotropic Acid MethodASTM D5037 Formaldehyde Content Analysis Using Colorimetric MethodASTM D5154 Formaldehyde Detection in Textile Finishing AgentsASTM D5190 Formaldehyde Determination in Finished FabricsASTM D5195 Quantitative Formaldehyde Testing in Textile SamplesASTM D5196 Formaldehyde Content Analysis by Chromotropic Acid MethodASTM D5196 Formaldehyde Determination by Chromotropic AcidASTM D5197 Formaldehyde Emission Measurement by Gas ChromatographyASTM D5198 Formaldehyde Release Measurement from FabricsASTM D5237 Formaldehyde Content in Finished Textile ProductsASTM D5792 Formaldehyde Extraction and Quantification MethodsASTM D6195 Formaldehyde Determination Using Spectrophotometric MethodASTM D6340 Analysis of Formaldehyde in Textile MaterialsASTM D6545 Determination of Formaldehyde Concentration in FabricsEN 14362-1 Detection of Azo Colorants in Textiles by Extraction and SpectrophotometryEN 14362-10 Analysis of Restricted Azo Dyes in TextilesEN 14362-11 Identification of Aromatic Amines by GC-MSEN 14362-12 Testing for Banned Azo Dyes in TextilesEN 14362-13 Identification and Quantification of Aromatic AminesEN 14362-14 Testing for Restricted Azo ColorantsEN 14362-15 Identification of Aromatic Amines by Liquid ChromatographyEN 14362-16 Testing for Carcinogenic Aromatic AminesEN 14362-2 Identification of Aromatic Amines by Chromatographic TechniquesEN 14362-3 Determination of Carcinogenic Aromatic Amines from Azo ColorantsEN 14362-4 Analysis of Textile Extracts for Azo Dye ResiduesEN 14362-5 Aromatic Amines Quantification by GC-MSEN 14362-6 Testing for Restricted Azo Dyes in Textile ProductsEN 14362-7 Identification of Aromatic Amines by High-Performance Liquid ChromatographyEN 14362-8 Testing for Aromatic Amines in Textile FibersEN 14362-9 Quantitative Analysis of Carcinogenic AminesISO 14184-1 Determination of Formaldehyde in Textiles – Part 1: Free and Hydrolyzed FormaldehydeISO 14184-2 Determination of Formaldehyde Using HPLCISO 14184-3 Formaldehyde Determination by Derivatization and SpectrophotometryISO 14184-4 Formaldehyde Testing Using Spectrophotometric TechniquesISO 14184-5 Determination of Formaldehyde Content Using ChromatographyISO 14184-6 Measurement of Formaldehyde Emission from Textile ProductsISO 14184-7 Determination of Formaldehyde in Textiles Using SpectroscopyISO 14184-8 Formaldehyde Emission Testing in Textile ProductsISO 17234 Azo Dye Release in Dyed and Printed TextilesISO 17234 Determination of Azo Dyes Released from TextilesISO 17234 Extraction and Analysis of Azo Colorants by HPLCISO 17234 Extraction and Quantification of Azo Dyes in Dyed FabricsISO 17234 Extraction of Azo Dyes from Textile MaterialsISO 17234 Quantitative Azo Dye Analysis by LC-MSISO 17234 Quantitative Determination of Azo Dyes by LC-MS/MSISO 17234-2 Extraction of Azo Dyes Using Liquid ChromatographyOECD 406 Skin Sensitization Study for Azo CompoundsOECD 410 Acute Dermal Toxicity Testing of Textile ChemicalsOECD 412 Subchronic Dermal Toxicity StudyOECD 428 Skin Absorption Testing of Formaldehyde in TextilesOECD 429 Assessment of Skin Sensitization by FormaldehydeOECD 429 In Vivo Skin Sensitization TestingOECD 429 Skin Sensitization Assessment for Azo DyesOECD 429 Skin Sensitization Testing Protocols for FormaldehydeOECD 429 Skin Sensitization Tests for Textile FormaldehydeOECD 429 Testing of Formaldehyde in Textile Products for Skin SensitizationOECD TG 405 Acute Dermal Irritation/Corrosion TestingOECD TG 420 Acute Dermal Toxicity Testing for Textile ChemicalsOECD TG 428 Skin Absorption: Azo Dye Penetration TestingOECD TG 429 Skin Sensitization Testing for FormaldehydeOECD TG 431 In Vitro Skin Sensitization Tests

Comprehensive Guide to OECD 407 Repeated Dose Dermal Toxicity Test Laboratory Testing Service

The OECD 407 Repeated Dose Dermal Toxicity Test is a laboratory test designed to assess the potential toxicity of substances applied to the skin. This test is governed by various international and national standards, which ensure that testing is conducted in a consistent and reliable manner.

Relevant Standards

  • ISO/TS 10993-23:2017 - Biological evaluation of medical devices Part 23: Tests for irritation and sensitization

  • ASTM E2556-14 - Standard Guide for Assessing the Dermal Irritation Potential of Chemicals

  • EN ISO 10993-10:2008A1:2015 - Biological evaluation of medical devices Part 10: Tests for irritation and sensitization

  • TSE (Turkish Standards Institution) TS EN ISO 10993-10:2009 - Biological evaluation of medical devices Part 10: Tests for irritation and sensitization

    • Legal and Regulatory Framework

    The OECD 407 Repeated Dose Dermal Toxicity Test is regulated by various international and national laws, including:

  • The European Unions (EU) Cosmetics Regulation (EC) No. 1223/2009

  • The EUs Biocidal Products Regulation (EU) No. 528/2012

  • The US FDAs Good Laboratory Practice Regulations (21 CFR Part 58)

    • International and National Standards

    The OECD 407 Repeated Dose Dermal Toxicity Test is governed by various international standards, including:

  • The International Organization for Standardization (ISO)

  • The American Society for Testing and Materials (ASTM)

  • The European Committee for Standardization (CEN)

  • The Turkish Standards Institution (TSE)

    • Standard Development Organizations

    Standard development organizations play a crucial role in developing and maintaining standards. These organizations include:

  • ISO

  • ASTM

  • CEN

  • TSE

    • How Standards Evolve and Get Updated

    Standards are regularly reviewed and updated to reflect the latest scientific knowledge and technological advancements. This ensures that testing is conducted using the most current and reliable methods.

    Standard Numbers and Scope

    The following standard numbers and their scope apply to the OECD 407 Repeated Dose Dermal Toxicity Test:

  • ISO/TS 10993-23:2017 - Biological evaluation of medical devices Part 23: Tests for irritation and sensitization

    • This standard specifies tests for irritation and sensitization.

  • ASTM E2556-14 - Standard Guide for Assessing the Dermal Irritation Potential of Chemicals

    • This guide provides a framework for assessing the dermal irritation potential of chemicals.

  • EN ISO 10993-10:2008A1:2015 - Biological evaluation of medical devices Part 10: Tests for irritation and sensitization

    • This standard specifies tests for irritation and sensitization.

    Standard Compliance Requirements

    Compliance with standards is mandatory in various industries, including:

  • Cosmetics industry (EC) No. 1223/2009)

  • Biocidal products industry (EU) No. 528/2012)

  • Medical devices industry (ISO/TS 10993-23:2017)

    • The OECD 407 Repeated Dose Dermal Toxicity Test is a critical component of product development, ensuring that substances applied to the skin are safe for human use.

    Why This Specific Test Is Needed

    This test is required to assess the potential toxicity of substances applied to the skin. The consequences of not performing this test include:

  • Potential harm to humans and animals

  • Non-compliance with regulatory requirements

  • Damage to a companys reputation

    • Business and Technical Reasons for Conducting OECD 407 Repeated Dose Dermal Toxicity Test

    This test is essential for various industries, including cosmetics, biocides, and medical devices. The benefits of conducting this test include:

  • Ensuring product safety and reliability

  • Complying with regulatory requirements

  • Building customer confidence and trust

    • Risk Factors and Safety Implications

    The OECD 407 Repeated Dose Dermal Toxicity Test identifies potential risks associated with substances applied to the skin, ensuring that products are safe for human use.

    Quality Assurance and Quality Control Aspects

    This test is conducted in accordance with international standards, ensuring consistency and reliability. The quality control measures include:

  • Calibration and validation of testing equipment

  • Regular maintenance and calibration of equipment

  • Use of certified reagents and materials

    • How This Test Contributes to Product Safety and Reliability

    The OECD 407 Repeated Dose Dermal Toxicity Test ensures that products are safe for human use, reducing the risk of adverse reactions.

    Competitive Advantages of Having This Testing Performed

    Conducting this test provides a competitive advantage by:

  • Ensuring compliance with regulatory requirements

  • Building customer confidence and trust

  • Differentiating products from competitors

    • The OECD 407 Repeated Dose Dermal Toxicity Test is governed by various international and national standards, ensuring consistency and reliability.

    Test Methodology

    The OECD 407 Repeated Dose Dermal Toxicity Test involves applying a test substance to the skin of a laboratory animal, assessing the potential toxicity of the substance.

    Interpretation of Results

    The results of this test are interpreted in accordance with international standards, identifying potential risks associated with substances applied to the skin.

    Conclusion

    The OECD 407 Repeated Dose Dermal Toxicity Test is an essential component of product development, ensuring that substances applied to the skin are safe for human use. Compliance with international and national standards ensures consistency and reliability.

    ---

    The OECD 407 Repeated Dose Dermal Toxicity Test involves applying a test substance to the skin of a laboratory animal, assessing the potential toxicity of the substance.

    Test Substance Preparation

    The test substance is prepared according to international standards, ensuring consistency and reliability.

    Application of Test Substance

    The test substance is applied to the skin of a laboratory animal in accordance with international standards.

    Observation and Recording of Results

    The results are observed and recorded in accordance with international standards, identifying potential risks associated with substances applied to the skin.

    Interpretation of Results

    The results of this test are interpreted in accordance with international standards, identifying potential risks associated with substances applied to the skin.

    Conclusion

    The OECD 407 Repeated Dose Dermal Toxicity Test is an essential component of product development, ensuring that substances applied to the skin are safe for human use. Compliance with international and national standards ensures consistency and reliability.

    ---

    The results of the OECD 407 Repeated Dose Dermal Toxicity Test are interpreted in accordance with international standards, identifying potential risks associated with substances applied to the skin.

    Classification of Irritation

    Irritation is classified according to international standards, ensuring consistency and reliability.

    Classification of Sensitization

    Sensitization is classified according to international standards, ensuring consistency and reliability.

    Conclusion

    The OECD 407 Repeated Dose Dermal Toxicity Test is an essential component of product development, ensuring that substances applied to the skin are safe for human use. Compliance with international and national standards ensures consistency and reliability.

    ---

    The test results of the OECD 407 Repeated Dose Dermal Toxicity Test provide valuable information on the potential toxicity of substances applied to the skin.

    Results Interpretation

    The results are interpreted in accordance with international standards, identifying potential risks associated with substances applied to the skin.

    Classification of Results

    The results are classified according to international standards, ensuring consistency and reliability.

    Conclusion

    The OECD 407 Repeated Dose Dermal Toxicity Test is an essential component of product development, ensuring that substances applied to the skin are safe for human use. Compliance with international and national standards ensures consistency and reliability.

    ---

    Certification and accreditation ensure that testing is conducted using the most current and reliable methods.

    Certification Process

    The certification process involves a third-party evaluation of testing facilities, ensuring compliance with international standards.

    Accreditation Process

    The accreditation process involves a third-party evaluation of testing facilities, ensuring compliance with international standards.

    Conclusion

    Certification and accreditation ensure that testing is conducted using the most current and reliable methods. Compliance with international and national standards ensures consistency and reliability.

    ---

    The OECD 407 Repeated Dose Dermal Toxicity Test is an essential component of product development, ensuring that substances applied to the skin are safe for human use. Compliance with international and national standards ensures consistency and reliability.

    Importance of Testing

    Testing is critical in ensuring product safety and reliability.

    Importance of Certification and Accreditation

    Certification and accreditation ensure that testing is conducted using the most current and reliable methods.

    Conclusion

    The OECD 407 Repeated Dose Dermal Toxicity Test is an essential component of product development, ensuring that substances applied to the skin are safe for human use. Compliance with international and national standards ensures consistency and reliability.

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