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oecd-412-subchronic-dermal-toxicity-study
Azo & Formaldehyde Testing ASTM D1331 Formaldehyde Emission Test in TextilesASTM D5035 Identification of Formaldehyde in Textile SamplesASTM D5036 Determination of Formaldehyde by Chromotropic Acid MethodASTM D5037 Formaldehyde Content Analysis Using Colorimetric MethodASTM D5154 Formaldehyde Detection in Textile Finishing AgentsASTM D5190 Formaldehyde Determination in Finished FabricsASTM D5195 Quantitative Formaldehyde Testing in Textile SamplesASTM D5196 Formaldehyde Content Analysis by Chromotropic Acid MethodASTM D5196 Formaldehyde Determination by Chromotropic AcidASTM D5197 Formaldehyde Emission Measurement by Gas ChromatographyASTM D5198 Formaldehyde Release Measurement from FabricsASTM D5237 Formaldehyde Content in Finished Textile ProductsASTM D5792 Formaldehyde Extraction and Quantification MethodsASTM D6195 Formaldehyde Determination Using Spectrophotometric MethodASTM D6340 Analysis of Formaldehyde in Textile MaterialsASTM D6545 Determination of Formaldehyde Concentration in FabricsEN 14362-1 Detection of Azo Colorants in Textiles by Extraction and SpectrophotometryEN 14362-10 Analysis of Restricted Azo Dyes in TextilesEN 14362-11 Identification of Aromatic Amines by GC-MSEN 14362-12 Testing for Banned Azo Dyes in TextilesEN 14362-13 Identification and Quantification of Aromatic AminesEN 14362-14 Testing for Restricted Azo ColorantsEN 14362-15 Identification of Aromatic Amines by Liquid ChromatographyEN 14362-16 Testing for Carcinogenic Aromatic AminesEN 14362-2 Identification of Aromatic Amines by Chromatographic TechniquesEN 14362-3 Determination of Carcinogenic Aromatic Amines from Azo ColorantsEN 14362-4 Analysis of Textile Extracts for Azo Dye ResiduesEN 14362-5 Aromatic Amines Quantification by GC-MSEN 14362-6 Testing for Restricted Azo Dyes in Textile ProductsEN 14362-7 Identification of Aromatic Amines by High-Performance Liquid ChromatographyEN 14362-8 Testing for Aromatic Amines in Textile FibersEN 14362-9 Quantitative Analysis of Carcinogenic AminesISO 14184-1 Determination of Formaldehyde in Textiles – Part 1: Free and Hydrolyzed FormaldehydeISO 14184-2 Determination of Formaldehyde Using HPLCISO 14184-3 Formaldehyde Determination by Derivatization and SpectrophotometryISO 14184-4 Formaldehyde Testing Using Spectrophotometric TechniquesISO 14184-5 Determination of Formaldehyde Content Using ChromatographyISO 14184-6 Measurement of Formaldehyde Emission from Textile ProductsISO 14184-7 Determination of Formaldehyde in Textiles Using SpectroscopyISO 14184-8 Formaldehyde Emission Testing in Textile ProductsISO 17234 Azo Dye Release in Dyed and Printed TextilesISO 17234 Determination of Azo Dyes Released from TextilesISO 17234 Extraction and Analysis of Azo Colorants by HPLCISO 17234 Extraction and Quantification of Azo Dyes in Dyed FabricsISO 17234 Extraction of Azo Dyes from Textile MaterialsISO 17234 Quantitative Azo Dye Analysis by LC-MSISO 17234 Quantitative Determination of Azo Dyes by LC-MS/MSISO 17234-2 Extraction of Azo Dyes Using Liquid ChromatographyOECD 406 Skin Sensitization Study for Azo CompoundsOECD 407 Repeated Dose Dermal Toxicity TestOECD 410 Acute Dermal Toxicity Testing of Textile ChemicalsOECD 428 Skin Absorption Testing of Formaldehyde in TextilesOECD 429 Assessment of Skin Sensitization by FormaldehydeOECD 429 In Vivo Skin Sensitization TestingOECD 429 Skin Sensitization Assessment for Azo DyesOECD 429 Skin Sensitization Testing Protocols for FormaldehydeOECD 429 Skin Sensitization Tests for Textile FormaldehydeOECD 429 Testing of Formaldehyde in Textile Products for Skin SensitizationOECD TG 405 Acute Dermal Irritation/Corrosion TestingOECD TG 420 Acute Dermal Toxicity Testing for Textile ChemicalsOECD TG 428 Skin Absorption: Azo Dye Penetration TestingOECD TG 429 Skin Sensitization Testing for FormaldehydeOECD TG 431 In Vitro Skin Sensitization Tests

OECD 412 Subchronic Dermal Toxicity Study Laboratory Testing Service: A Comprehensive Guide

The OECD 412 Subchronic Dermal Toxicity Study is a standardized laboratory test designed to assess the subchronic dermal toxicity of chemicals. This test is governed by various international and national standards, which are outlined below.

Relevant Standards:

  • ISO 10993-23:2012 Biological evaluation of medical devices Part 23: Tests for irritation
  • ASTM E2525-08 Standard Guide for Conducting Acute Dermal Irritation Reactions in the Rabbit
  • EN 14750:2006 Chemicals - Guidance on the use of in vitro methods for skin corrosion/irritation and eye irritation testing
  • Legal and Regulatory Framework:

    The OECD 412 Subchronic Dermal Toxicity Study is regulated by various laws and regulations, including:

  • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) Regulation (EC) No 1907/2006
  • EU Cosmetic Directive 76/768/EEC
  • US FDAs Good Laboratory Practice Regulations (21 CFR Part 58)
  • International and National Standards:

    The OECD 412 Subchronic Dermal Toxicity Study is a global standard, recognized by various international organizations, including:

  • Organisation for Economic Co-operation and Development (OECD)
  • International Organization for Standardization (ISO)
  • American Society for Testing and Materials (ASTM)
  • National standards also play a crucial role in regulating this testing service. For example, the EUs Cosmetic Directive requires that all cosmetic products undergo dermal irritation testing.

    Standard Development Organizations:

    The development of standards is overseen by various organizations, including:

  • ISO
  • ASTM
  • EN
  • These organizations work together to develop and update standards, ensuring they remain relevant and effective.

    Standard Evolution and Updates:

    Standards are constantly evolving as new scientific evidence emerges. For example, the OECD 412 Subchronic Dermal Toxicity Study has undergone several updates since its inception.

    Specific Standard Numbers and Their Scope:

    The following standard numbers apply to the OECD 412 Subchronic Dermal Toxicity Study:

  • ISO 10993-23:2012
  • ASTM E2525-08
  • EN 14750:2006
  • Each of these standards outlines specific requirements for conducting this testing service.

    Standard Compliance Requirements for Different Industries:

    Different industries have varying compliance requirements. For example:

  • The EUs Cosmetic Directive requires that all cosmetic products undergo dermal irritation testing.
  • REACH Regulation (EC) No 1907/2006 requires that all chemicals undergo subchronic dermal toxicity testing.
  • Standard-Related Information Conclusion:

    The OECD 412 Subchronic Dermal Toxicity Study is governed by various international and national standards. Understanding these standards is crucial for ensuring compliance with regulatory requirements.

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    The OECD 412 Subchronic Dermal Toxicity Study is a critical testing service required by various industries. This section outlines the business and technical reasons for conducting this test.

    Why This Test Is Needed:

    This testing service is essential for:

  • Ensuring product safety and reliability
  • Meeting regulatory requirements
  • Maintaining customer confidence and trust
  • Business and Technical Reasons for Conducting OECD 412 Subchronic Dermal Toxicity Study Testing:

    The business and technical reasons for conducting this test include:

  • Compliance with regulatory requirements
  • Prevention of product liability claims
  • Ensuring product quality and safety
  • Meeting consumer expectations
  • Consequences of Not Performing This Test:

    Failure to conduct this testing service can result in:

  • Product recalls
  • Loss of customer confidence and trust
  • Regulatory non-compliance
  • Financial losses
  • Industries and Sectors That Require This Testing:

    The following industries require the OECD 412 Subchronic Dermal Toxicity Study testing service:

  • Cosmetics industry
  • Pharmaceutical industry
  • Chemical industry
  • Medical device industry
  • Risk Factors and Safety Implications:

    This testing service helps mitigate risks associated with dermal irritation, including:

  • Skin inflammation
  • Irritation and allergic reactions
  • Eye irritation
  • Quality Assurance and Quality Control Aspects:

    Eurolab ensures that all OECD 412 Subchronic Dermal Toxicity Study testing is conducted in accordance with international standards. Our quality assurance and control measures include:

  • Calibration of equipment
  • Validation of test methods
  • Regular training and certification of personnel
  • Contribution to Product Safety and Reliability:

    This testing service contributes significantly to product safety and reliability by:

  • Identifying potential dermal irritation hazards
  • Ensuring compliance with regulatory requirements
  • Maintaining customer confidence and trust
  • Competitive Advantages of Having This Testing Performed:

    Performing the OECD 412 Subchronic Dermal Toxicity Study testing service provides several competitive advantages, including:

  • Compliance with regulatory requirements
  • Prevention of product liability claims
  • Ensuring product quality and safety
  • Meeting consumer expectations
  • ---

    Standard Requirements and Needs Conclusion:

    The OECD 412 Subchronic Dermal Toxicity Study is a critical testing service required by various industries. Understanding the business and technical reasons for conducting this test ensures compliance with regulatory requirements.

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