OECD TG 428 Skin Absorption: Azo Dye Penetration Testing

OECD TG 428 Skin Absorption: Azo Dye Penetration Testing - A Comprehensive Guide

Standard-Related Information

The OECD (Organisation for Economic Co-operation and Development) Test Guideline No. 428, Skin Absorption: In Vitro Method is a widely accepted standard for testing the skin absorption of chemicals, including azo dyes. This guideline provides a framework for conducting in vitro tests to assess the skin absorption potential of substances.

International and National Standards

The OECD TG 428 is based on various international and national standards, including:

Standard Development Organizations

The OECD TG 428 was developed by the OECD Working Party on Chemicals, Pesticides and Biotechnology (WCPB), in collaboration with other international organizations and standard development bodies.

Evolution of Standards

Standards evolve over time to reflect new scientific knowledge, technological advancements, and changing regulatory requirements. The OECD TG 428 has undergone several revisions since its initial publication in 2004.

Standard Compliance Requirements

Compliance with the OECD TG 428 is mandatory for certain industries, such as cosmetics, pharmaceuticals, and chemicals. Regulatory authorities, including the European Chemicals Agency (ECHA), require compliance with this standard for certain substances.

Why This Test Is Needed and Required

The skin absorption of azo dyes can pose significant health risks to humans and the environment. Conducting OECD TG 428 testing ensures that these substances are safe for use in various applications, such as cosmetics, textiles, and pharmaceuticals.

Business and Technical Reasons for Conducting OECD TG 428 Testing

Consequences of Not Performing This Test

Failure to conduct OECD TG 428 testing can result in non-compliance with regulatory requirements, product recalls, and reputational damage.

Industries and Sectors That Require This Testing

Risk Factors and Safety Implications

Quality Assurance and Control Aspects

Test Conditions and Methodology

The OECD TG 428 testing involves the following steps:

1. Sample Preparation: Prepare the azo dye samples according to the standard protocol.

2. Testing Equipment and Instruments: Use a suitable skin simulator or receptor fluid to mimic human skin absorption.

3. Testing Environment Requirements: Maintain a controlled environment with specific temperature, humidity, and pressure conditions.

4. Measurement and Analysis Methods: Measure the absorbed amount of azo dye using various techniques, such as HPLC (High-Performance Liquid Chromatography) or GC (Gas Chromatography).

5. Calibration and Validation Procedures: Calibrate and validate testing equipment according to the standard protocol.

Test Reporting and Documentation

The OECD TG 428 test report should include:

Why This Test Should Be Performed

Performing the OECD TG 428 skin absorption testing provides numerous benefits, including:

Why Eurolab Should Provide This Service

Eurolab offers state-of-the-art equipment, qualified personnel, and certified facilities to provide high-quality OECD TG 428 skin absorption testing services. Our team is committed to ensuring compliance with regulatory requirements and providing accurate test results.

Customer Testimonials and Success Stories

I have been working with Eurolab for several years, and their expertise in OECD TG 428 testing has been invaluable. Their professionalism and attention to detail ensure that our products meet the highest safety standards. - John Doe, Quality Manager at XYZ Corporation

We were able to reduce our testing cycle time by 50 thanks to Eurolabs efficient testing procedures and advanced equipment. Their team is knowledgeable and responsive to our needs. - Jane Smith, Research Scientist at ABC University