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aoac-201123-lc-msms-determination-of-sulfonamides-in-meat
Pesticide & Veterinary Drug Residues AOAC 2003.06 Chloramphenicol residue analysis in honeyAOAC 2004.08 Hormone residue detection in eggsAOAC 2006.03 Quantitation of residues in dairy productsAOAC 2007.01 Pesticide residue analysis in fruits and vegetables by LC-MS/MSAOAC 2008.05 Veterinary residue analysis in milk powderAOAC 2009.01 Pesticide residues in cocoa and chocolateAOAC 2010.01 Multiresidue analysis of pesticides in baby foodAOAC 2014.10 Tetracycline residues in fish and shellfish by ELISAAOAC 2015.06 Detection of pesticide residues in honey and bee productsAOAC 2016.04 Veterinary drug testing in poultry productsAOAC 2016.09 Veterinary drugs in seafood samplesAOAC 2017.02 Fluoroquinolone residue detection in beefAOAC 2017.09 Pesticide residues in citrus fruitsAOAC 2018.03 Veterinary drug residues in milk by LC-MS/MSAOAC 2018.09 Detection of macrolides in pork and beefAOAC 2019.02 Detection of β-lactam antibiotics in bovine milkAOAC 2020.04 LC-MS analysis of antiparasitics in sheep meatAOAC 2020.05 Multi-class pesticide screening in tea leavesAOAC 2021.06 Veterinary residues in dried meat productsAOAC 2022.01 Carbamate detection in vegetablesAOAC 2023.02 Veterinary drug screening in animal fatCAC/MRL 01 Maximum Residue Limits of Pesticides in Food Products TestingCodex CAC/MRL 1 Establishing pesticide MRLs in cereals and grainsCodex CXG 71-2009 Guidelines on residue monitoring programsCodex GL 56 Guidelines on Good Laboratory Practice for Pesticide Residue AnalysisCodex GL 56 Guidelines on performance criteria for methods of analysis for pesticidesCodex GL 71 Sampling for determination of pesticide residuesCodex GL 81 Good laboratory practices for pesticide residue testingCodex GL 90 Guideline levels for residues of veterinary drugs in foodCodex MRL Database Reference MRLs for pesticide-veterinary crossoverEPA 1657 Determination of pesticide metabolites in cropsEPA 3052 Determination of heavy metals in fertilizers and feed via acid digestionEPA 310.1 Herbicide detection in plant-based samplesEPA 314.1 Pesticide testing in animal urine samplesEPA 40 CFR Part 180 Analysis of Tolerances for Pesticide Chemical ResiduesEPA 5035A Sample preservation for volatile pesticide residue testingEPA 507 Pesticide analysis in drinking water and juicesEPA 535 Determination of chloroacetanilide herbicides in produceEPA 549.2 Aldicarb and related pesticide testing in plant tissueEPA 551.1 Determination of volatile pesticide residues in vegetablesEPA 6010D Trace metals in feed samples for pesticide contaminationEPA 608.3 Detection of pesticides in fat-rich animal tissuesEPA 8000C General protocols for pesticide residue identificationEPA 8081B Organochlorine pesticide detection by gas chromatographyEPA 8141B Organophosphorus pesticides in food matricesEPA 8151A Herbicide testing in soil and agricultural produceEPA 8151B LC-MS/MS testing of veterinary pesticide synergy effectsEPA 8270E Determination of semi-volatile pesticide residues in foodEPA 8321B Analysis of polar pesticides in animal tissues by HPLC-MSEPA 8325B Emerging pesticide residues in herbal medicinesEPA 8327 LC-MS analysis of pesticide degradation products in meatEPA 8330A Analysis of nitroaromatic pesticide residues in grainEU 2002/657/EC Validation of analytical methods for veterinary drug residuesEU 2005/34/EC Identification of residues in fresh meatEU 2009/128/EC Sustainable use of pesticides in food safety testingEU 2018/782 Residue control plan for animal-based food productsEU 2021/601 Monitoring of pesticide residues in organic foodEU 2022/617 Harmonization of veterinary residue testing protocolsEU 37/2010 Annex II Veterinary medicine residue validationEU 37/2010 Veterinary drug residue limits in foodstuffs of animal originEU 396/2005 Compliance Testing for Pesticide Residues in Fruits and VegetablesEU 396/2005 Harmonized limits for pesticide residues in food and feedEU 396/2005 Maximum residue limits of pesticides in agricultural products testingEU 625/2017 Compliance testing of veterinary drugs in aquacultureEU 744/2004 Residue control measures in aquacultureEU 96/23/EC Monitoring substances in live animals and animal productsEU SANTE/11813/2017 Sampling procedures for pesticide testingEU SANTE/12682/2019 Pesticide residues determination by QuEChERS methodEU SANTE/2020/12830 Confirmatory methods for residue analysisFAO/WHO Manual of Pesticide Residue Analysis in Agricultural CommoditiesISO 13395 Nitrite/nitrate detection in vegetables and fruitsISO 15662 Pesticide residue screening using modified QuEChERSISO 15952 Pesticide residue testing in animal feedingstuffsISO 17094 Multiclass pesticide residue testing in oilseedsISO 17190 Detection of residues in fermented animal feedISO 18330 Pesticide and veterinary drug residue detection in herbsISO 18385 Measurement of pesticide residue cross-contaminationISO 1842 Analysis of pesticide residues in feed raw materialsISO 18512 Pesticide and antibiotic residues in animal dungISO 20418 Veterinary antibiotic residues in bovine serumISO 21010 Rapid screening for multi-class residues in animal tissueISO 21458 Screening of pesticide residues using multi-residue methodsISO 22855 Determination of pesticide degradation products in foodISO 22866 Determination of Spray Drift in Field Conditions for Pesticide ApplicationISO 22892 Analysis of persistent organic pollutants in livestockISO 23161 Screening of veterinary drug residues in eggsISO 23690 Determination of pesticide metabolites in animal feedISO 24662 Pesticide residue analysis in dried plant materialsISO 24687 Pesticide metabolite residue determination in poultryISO 25102 Multiresidue pesticide testing in spices and condimentsISO 6468 Pesticide residue analysis in water using liquid-liquid extractionJECFA Evaluation-Based Testing of Veterinary Drug Residues in Animal ProductsJECFA Pesticide residue risk evaluation for animal-derived productsJECFA Residue analysis of growth promoters in animal tissuesJECFA Residue evaluation of antibiotics in livestockJECFA Residue evaluation of veterinary drugs in cattle and poultryJECFA Residue limit setting for antimicrobials in livestockJECFA Risk assessment methodology for pesticide residue evaluationJECFA Risk-based residue evaluation for export commoditiesOECD TG 509 Residue Studies in Livestock for Veterinary Drugs DetectionSANCO/12495/2011 Method Validation for Pesticide Residue Analysis in FoodsVICH GL49 Risk Assessment Studies for Veterinary Medicinal Product Residues

AOAC 2011.23 LC-MS/MS Determination of Sulfonamides in Meat: Eurolabs Laboratory Testing Service

The AOAC 2011.23 method for the determination of sulfonamides in meat by liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a widely accepted and recognized standard for testing sulfonamide residues in animal-derived food products. This standard is developed and published by the Association of Official Analytical Chemists (AOAC), an international organization that establishes and maintains standards for analytical methods.

The AOAC 2011.23 method is based on ISO/TS 18743:2009, which provides guidelines for the validation of analytical methods for residues in animal-derived food products. This standard requires laboratories to follow a rigorous testing protocol to ensure accuracy, precision, and reliability of test results.

In addition to the AOAC 2011.23 method, several other international standards govern the testing of sulfonamides in meat, including:

  • ISO/TS 18743:2009 (Guidelines for the validation of analytical methods for residues in animal-derived food products)

  • EU Regulation No. 657/2002 (Setting maximum residue limits for veterinary medicinal products in foodstuffs of animal origin)

  • FDA Guidance for Industry (Food Defect Action Levels)

    • These standards emphasize the importance of accurate and reliable testing to ensure public health and safety.

    The AOAC 2011.23 LC-MS/MS determination of sulfonamides in meat is a critical test required by regulatory agencies, such as the US FDA and the European Commission, to ensure compliance with maximum residue limits (MRLs) for veterinary medicinal products.

    The main reasons for conducting this test are:

  • To ensure public health and safety by detecting residues of sulfonamide antibiotics in animal-derived food products

  • To prevent the misuse of antibiotics in agriculture, which can lead to antibiotic resistance and compromise human health

  • To maintain consumer confidence in the quality and safety of meat products

    • The consequences of not performing this test include:

  • Non-compliance with regulatory requirements

  • Risk of contamination and exposure to sulfonamide residues

  • Loss of customer trust and reputation damage for food manufacturers and retailers

    • The industries and sectors that require this testing are:

  • Meat processing and manufacturing

  • Animal feed production

  • Veterinary medicine and pharmaceuticals

    • The risk factors and safety implications associated with sulfonamide residues in meat include:

  • Antibiotic resistance

  • Human health risks (e.g., cancer, allergic reactions)

  • Environmental contamination

    • The AOAC 2011.23 LC-MS/MS determination of sulfonamides in meat involves the following steps:

    1. Sample Preparation: Meat samples are homogenized, extracted with a solvent mixture, and cleaned up using solid-phase extraction (SPE).

    2. LC-MS/MS Analysis: The extract is analyzed using a high-performance liquid chromatography-tandem mass spectrometry system.

    3. Data Acquisition and Processing: Data are acquired and processed using specialized software to detect and quantify sulfonamide residues.

    The testing equipment and instruments used include:

  • HPLC system (e.g., Agilent, Shimadzu)

  • MS/MS analyzer (e.g., Applied Biosystems, Bruker)

  • SPE columns (e.g., Waters, Phenomenex)

    • The test report format for the AOAC 2011.23 LC-MS/MS determination of sulfonamides in meat includes:

  • Sample identification

  • Test method used

  • Results and detection limits

  • Certificates of analysis

  • Reporting standards and formats (e.g., ISO, EU)

    • The benefits of performing the AOAC 2011.23 LC-MS/MS determination of sulfonamides in meat include:

  • Risk Assessment: Early detection of sulfonamide residues enables risk assessment and mitigation

  • Quality Assurance: Compliance with regulatory requirements ensures product safety and quality

  • Competitive Advantage: Accreditation to international standards enhances reputation and market positioning

  • Cost Savings: Detection of contaminants at an early stage reduces costs associated with product recall or rejection

    • Eurolab offers a comprehensive laboratory testing service for AOAC 2011.23 LC-MS/MS determination of sulfonamides in meat, including:

  • State-of-the-Art Equipment: High-performance HPLC and MS/MS systems

  • Expert Analytical Team: Experienced scientists with extensive knowledge of analytical methods and regulations

  • Accreditation to International Standards: Compliance with AOAC 2011.23 method and other relevant standards (e.g., ISO, EU)

  • Prompt Reporting: Timely delivery of test results and certificates of analysis

    • Need help or have a question?
    Contact us for prompt assistance and solutions.

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