EUROLAB
aoac-201803-veterinary-drug-residues-in-milk-by-lc-msms
Pesticide & Veterinary Drug Residues AOAC 2003.06 Chloramphenicol residue analysis in honeyAOAC 2004.08 Hormone residue detection in eggsAOAC 2006.03 Quantitation of residues in dairy productsAOAC 2007.01 Pesticide residue analysis in fruits and vegetables by LC-MS/MSAOAC 2008.05 Veterinary residue analysis in milk powderAOAC 2009.01 Pesticide residues in cocoa and chocolateAOAC 2010.01 Multiresidue analysis of pesticides in baby foodAOAC 2011.23 LC-MS/MS determination of sulfonamides in meatAOAC 2014.10 Tetracycline residues in fish and shellfish by ELISAAOAC 2015.06 Detection of pesticide residues in honey and bee productsAOAC 2016.04 Veterinary drug testing in poultry productsAOAC 2016.09 Veterinary drugs in seafood samplesAOAC 2017.02 Fluoroquinolone residue detection in beefAOAC 2017.09 Pesticide residues in citrus fruitsAOAC 2018.09 Detection of macrolides in pork and beefAOAC 2019.02 Detection of β-lactam antibiotics in bovine milkAOAC 2020.04 LC-MS analysis of antiparasitics in sheep meatAOAC 2020.05 Multi-class pesticide screening in tea leavesAOAC 2021.06 Veterinary residues in dried meat productsAOAC 2022.01 Carbamate detection in vegetablesAOAC 2023.02 Veterinary drug screening in animal fatCAC/MRL 01 Maximum Residue Limits of Pesticides in Food Products TestingCodex CAC/MRL 1 Establishing pesticide MRLs in cereals and grainsCodex CXG 71-2009 Guidelines on residue monitoring programsCodex GL 56 Guidelines on Good Laboratory Practice for Pesticide Residue AnalysisCodex GL 56 Guidelines on performance criteria for methods of analysis for pesticidesCodex GL 71 Sampling for determination of pesticide residuesCodex GL 81 Good laboratory practices for pesticide residue testingCodex GL 90 Guideline levels for residues of veterinary drugs in foodCodex MRL Database Reference MRLs for pesticide-veterinary crossoverEPA 1657 Determination of pesticide metabolites in cropsEPA 3052 Determination of heavy metals in fertilizers and feed via acid digestionEPA 310.1 Herbicide detection in plant-based samplesEPA 314.1 Pesticide testing in animal urine samplesEPA 40 CFR Part 180 Analysis of Tolerances for Pesticide Chemical ResiduesEPA 5035A Sample preservation for volatile pesticide residue testingEPA 507 Pesticide analysis in drinking water and juicesEPA 535 Determination of chloroacetanilide herbicides in produceEPA 549.2 Aldicarb and related pesticide testing in plant tissueEPA 551.1 Determination of volatile pesticide residues in vegetablesEPA 6010D Trace metals in feed samples for pesticide contaminationEPA 608.3 Detection of pesticides in fat-rich animal tissuesEPA 8000C General protocols for pesticide residue identificationEPA 8081B Organochlorine pesticide detection by gas chromatographyEPA 8141B Organophosphorus pesticides in food matricesEPA 8151A Herbicide testing in soil and agricultural produceEPA 8151B LC-MS/MS testing of veterinary pesticide synergy effectsEPA 8270E Determination of semi-volatile pesticide residues in foodEPA 8321B Analysis of polar pesticides in animal tissues by HPLC-MSEPA 8325B Emerging pesticide residues in herbal medicinesEPA 8327 LC-MS analysis of pesticide degradation products in meatEPA 8330A Analysis of nitroaromatic pesticide residues in grainEU 2002/657/EC Validation of analytical methods for veterinary drug residuesEU 2005/34/EC Identification of residues in fresh meatEU 2009/128/EC Sustainable use of pesticides in food safety testingEU 2018/782 Residue control plan for animal-based food productsEU 2021/601 Monitoring of pesticide residues in organic foodEU 2022/617 Harmonization of veterinary residue testing protocolsEU 37/2010 Annex II Veterinary medicine residue validationEU 37/2010 Veterinary drug residue limits in foodstuffs of animal originEU 396/2005 Compliance Testing for Pesticide Residues in Fruits and VegetablesEU 396/2005 Harmonized limits for pesticide residues in food and feedEU 396/2005 Maximum residue limits of pesticides in agricultural products testingEU 625/2017 Compliance testing of veterinary drugs in aquacultureEU 744/2004 Residue control measures in aquacultureEU 96/23/EC Monitoring substances in live animals and animal productsEU SANTE/11813/2017 Sampling procedures for pesticide testingEU SANTE/12682/2019 Pesticide residues determination by QuEChERS methodEU SANTE/2020/12830 Confirmatory methods for residue analysisFAO/WHO Manual of Pesticide Residue Analysis in Agricultural CommoditiesISO 13395 Nitrite/nitrate detection in vegetables and fruitsISO 15662 Pesticide residue screening using modified QuEChERSISO 15952 Pesticide residue testing in animal feedingstuffsISO 17094 Multiclass pesticide residue testing in oilseedsISO 17190 Detection of residues in fermented animal feedISO 18330 Pesticide and veterinary drug residue detection in herbsISO 18385 Measurement of pesticide residue cross-contaminationISO 1842 Analysis of pesticide residues in feed raw materialsISO 18512 Pesticide and antibiotic residues in animal dungISO 20418 Veterinary antibiotic residues in bovine serumISO 21010 Rapid screening for multi-class residues in animal tissueISO 21458 Screening of pesticide residues using multi-residue methodsISO 22855 Determination of pesticide degradation products in foodISO 22866 Determination of Spray Drift in Field Conditions for Pesticide ApplicationISO 22892 Analysis of persistent organic pollutants in livestockISO 23161 Screening of veterinary drug residues in eggsISO 23690 Determination of pesticide metabolites in animal feedISO 24662 Pesticide residue analysis in dried plant materialsISO 24687 Pesticide metabolite residue determination in poultryISO 25102 Multiresidue pesticide testing in spices and condimentsISO 6468 Pesticide residue analysis in water using liquid-liquid extractionJECFA Evaluation-Based Testing of Veterinary Drug Residues in Animal ProductsJECFA Pesticide residue risk evaluation for animal-derived productsJECFA Residue analysis of growth promoters in animal tissuesJECFA Residue evaluation of antibiotics in livestockJECFA Residue evaluation of veterinary drugs in cattle and poultryJECFA Residue limit setting for antimicrobials in livestockJECFA Risk assessment methodology for pesticide residue evaluationJECFA Risk-based residue evaluation for export commoditiesOECD TG 509 Residue Studies in Livestock for Veterinary Drugs DetectionSANCO/12495/2011 Method Validation for Pesticide Residue Analysis in FoodsVICH GL49 Risk Assessment Studies for Veterinary Medicinal Product Residues

AOAC 2018.03 Veterinary Drug Residues in Milk by LC-MS/MS Laboratory Testing Service Provided by Eurolab: A Comprehensive Guide

Standard-Related Information

The AOAC 2018.03 standard for veterinary drug residues in milk by LC-MS/MS testing is a widely accepted and recognized method for detecting and quantifying various veterinary drugs in milk samples. This standard is developed by the Association of Official Analytical Chemists (AOAC) International, a non-profit organization that sets standards for laboratory testing.

International Standards

The AOAC 2018.03 standard is based on several international standards, including:

  • ISO 17025:2005 General requirements for the competence of testing and calibration laboratories

  • ISO/IEC 17065:2012 Conformity assessment - Requirements for bodies certifying products, processes and services

  • EU Directive 96/23/EC on the protection of animals used for experimental and other scientific purposes

    • National Standards

    In addition to international standards, national standards also apply to AOAC 2018.03 testing. These include:

  • USDA (United States Department of Agriculture) standards for milk testing

  • EU regulations for veterinary drug residues in animal-derived products

  • Australian Government Department of Agriculture and Water Resources standards for milk testing

    • Standard Development Organizations

    The AOAC International is a standard development organization that sets standards for laboratory testing, including the AOAC 2018.03 standard. Other standard development organizations include:

  • ISO (International Organization for Standardization)

  • ASTM (American Society for Testing and Materials)

  • EN (European Committee for Standardization)

    • Standard Evolution and Update

    Standards evolve over time to reflect changes in technology, science, and regulations. The AOAC 2018.03 standard has undergone several updates since its initial publication, including:

  • AOAC 2007.01: First edition of the standard

  • AOAC 2012.12: Second edition of the standard

  • AOAC 2018.03: Current edition of the standard

    • Standard Numbers and Scope

    The AOAC 2018.03 standard has several numbers and scopes, including:

  • Standard number: AOAC 2018.03

  • Title: Veterinary drug residues in milk by LC-MS/MS testing

  • Scope: The standard covers the detection and quantification of various veterinary drugs in milk samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS)

    • Standard Compliance Requirements

    Compliance with AOAC 2018.03 standards is required for laboratories that perform veterinary drug residues in milk by LC-MS/MS testing. This includes:

  • Accreditation to ISO 17025:2005

  • Certification to EU Directive 96/23/EC

  • Compliance with USDA and Australian Government Department of Agriculture and Water Resources regulations

    • Standard-Related Information

    The AOAC 2018.03 standard is a widely accepted and recognized method for detecting and quantifying various veterinary drugs in milk samples. This standard is developed by the Association of Official Analytical Chemists (AOAC) International, a non-profit organization that sets standards for laboratory testing.

    Standard Requirements and Needs

    The AOAC 2018.03 standard is required to ensure the safety of milk products consumed by humans and animals. The consequences of not performing this test include:

  • Non-compliance with regulations

  • Risk of contamination and harm to consumers

  • Damage to reputation and business

    • Business and Technical Reasons for Conducting AOAC 2018.03 Testing

    The business and technical reasons for conducting AOAC 2018.03 testing include:

  • Compliance with regulations and standards

  • Ensuring the safety of milk products consumed by humans and animals

  • Protecting the reputation and business of dairy farms and processors

  • Detecting and quantifying various veterinary drugs in milk samples

    • Consequences of Not Performing This Test

    The consequences of not performing this test include:

  • Non-compliance with regulations

  • Risk of contamination and harm to consumers

  • Damage to reputation and business

    • Industries and Sectors that Require This Testing

    The industries and sectors that require AOAC 2018.03 testing include:

  • Dairy farms

  • Milk processors

  • Regulatory agencies

  • Food safety organizations

    • Risk Factors and Safety Implications

    The risk factors and safety implications of not performing this test include:

  • Risk of contamination and harm to consumers

  • Damage to reputation and business

  • Non-compliance with regulations

    • Quality Assurance and Quality Control Aspects

    The quality assurance and quality control aspects of AOAC 2018.03 testing include:

  • Accreditation to ISO 17025:2005

  • Certification to EU Directive 96/23/EC

  • Compliance with USDA and Australian Government Department of Agriculture and Water Resources regulations

    • AOAC 2018.03 Testing Process

    The AOAC 2018.03 testing process includes:

    1. Sample collection and preparation

    2. Extraction and cleanup

    3. LC-MS/MS analysis

    4. Data interpretation and reporting

    Equipment and Materials Required for AOAC 2018.03 Testing

    The equipment and materials required for AOAC 2018.03 testing include:

  • Liquid chromatography-tandem mass spectrometry (LC-MS/MS) instrument

  • Sample preparation equipment

  • Extraction and cleanup reagents

    • AOAC 2018.03 Testing Methods

    The AOAC 2018.03 testing methods include:

  • QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe)

  • Liquid-liquid extraction (LLE)

  • Solid-phase extraction (SPE)

    • Data Interpretation and Reporting

    The data interpretation and reporting aspects of AOAC 2018.03 testing include:

  • Calculating the concentrations of veterinary drugs

  • Comparing the results to established limits

  • Generating reports for regulatory agencies

    • AOAC 2018.03 Testing Certifications

    The AOAC 2018.03 testing certifications include:

  • ISO 17025:2005 accreditation

  • EU Directive 96/23/EC certification

  • USDA and Australian Government Department of Agriculture and Water Resources compliance

    • Conclusion

    In conclusion, the AOAC 2018.03 standard for veterinary drug residues in milk by LC-MS/MS testing is a widely accepted and recognized method for detecting and quantifying various veterinary drugs in milk samples. This standard is developed by the Association of Official Analytical Chemists (AOAC) International, a non-profit organization that sets standards for laboratory testing.

    Recommendations

    Based on this comprehensive guide, we recommend:

  • Laboratories that perform veterinary drug residues in milk by LC-MS/MS testing should be accredited to ISO 17025:2005 and certified to EU Directive 96/23/EC.

  • Dairy farms and processors should ensure that their milk products are tested for veterinary drugs using AOAC 2018.03 methods.

  • Regulatory agencies should require laboratories to comply with AOAC 2018.03 standards.

    • Limitations

    The limitations of this guide include:

  • The guide is based on the AOAC 2018.03 standard, which may not be applicable in all countries or regions.

  • The guide does not provide detailed information on equipment and materials required for AOAC 2018.03 testing.

    • Future Developments

    Future developments in AOAC 2018.03 testing include:

  • Updates to the standard to reflect changes in technology, science, and regulations

  • Development of new methods for detecting and quantifying veterinary drugs in milk samples

    • By following this comprehensive guide, laboratories can ensure compliance with AOAC 2018.03 standards and provide accurate and reliable results for veterinary drug residues in milk by LC-MS/MS testing.

    Appendix

    The appendix includes:

  • AOAC 2018.03 standard document

  • List of equipment and materials required for AOAC 2018.03 testing

  • List of industries and sectors that require AOAC 2018.03 testing

    • Need help or have a question?
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